Endocrine Abstracts

Background: Multiple endocrine neoplasia type 1 (MEN1), is an autosomal dominant inherited disorder with high penentrance, characterized by the onset of multiple tumors, mainly in parathyroid, pituitary gland and gastroenteropancreatic tract. During the course of the disease pituitary adenomas (PA) occur in 20-65%, rarely as first clinical manifestation, and are often described as larger, more aggressive, and more resistant to conventional therapy than their sporadic counterpa...

Background: Fine needle aspiration (FNA) is the diagnostic procedure of choice in the evaluation of thyroid nodules. Nodules with indeterminate cytological categories, Tir3A and Tir3B according to Italian cytological classification, pose diagnostic challenges in clinical practice and are frequently submitted to diagnostic surgery. CytoFoam Core (CF) (Diapath, Martinengo, Italy) uses an absorbent foam device inserted into the needle hub to collect the cytological sample aspirat...

During development, gonadotropin releasing hormone (GnRH) neurons are born in the nasal placode and migrate to the hypothalamus, where they position to regulate sexual reproduction by the pulsatile release of GnRH. Defective GnRH neuron development or action may lead to GnRH deficiency (GD) which is characterized by absent or delayed puberty (1). GD can also be present as a trait shared by several complex neurodevelopmental disorders (NDDs), such as cerebellar ataxia, developm...

Background: In 2014 a new Italian classification system of thyroid cytology divided the indeterminate TIR3 category in two groups, TIR3A and TIR3B, aiming to reduce unnecessary thyroidectomies. The reported risk of malignancy is: TIR3A: <10%, suggesting follow-up and possible FNA repetition after 6 months, and TIR3B: 15-30%, recommending surgery.Objectives: We aimed to: evaluate the histological prevalence of malignancy in TIR3A and TIR3B nodules in ...

In recent years, US-guided thermal ablation techniques have been proposed as a therapeutic alternative to traditional surgery or to metabolic radiotherapy for thyroid nodes. RFA is one of the most used technique and experience in both ultrasound and ultrasound interventional is important for results and minimizing complications. We present our experience after 1 year of activity on the first 33 patients with thyroid nodules treated with RFA. The nodules were evaluated by ultra...

Recently ultrasound-guide radiofrequency thermal ablation has been proposed as an effective and safe procedure for treating patients who have low risk papillary thyroid microcarcinomas or are unfit for surgery. We present the case of a 56 years old patient with a small (10 mm) thyroid nodule diagnosed as TIR 4, suspect citology for papillary carcinoma after fine needle aspiration. The nodule was also studied with CEUS (Sonovue US contrast medium) which showed increased vascula...

Introduction: The long pentraxine-3 (PTX3) is a key component of humoral innate immunity that is expressed in various cell types during stress and tissue injury. PTX3 also acts like an oncosuppressor regulating tumor-promoting inflammation and it is implicated in tissue repair and autoimmunity. Autoimmune disease, tissue remodelling and oncogenesis often coexist in the thyroid. PTX3 role in thyroid disease is still unknown. Aim of the study is to evaluate if plasmatic levels o...

Introduction: Acromegaly is a chronic disease that requires continuous follow-up and examinations over time. During the COVID-19 pandemic outbreak many endocrinological scientific societies recommend to reduce pituitary patient access to hospital facilities to decrease risk of infection. Aim: The aim of our study is to evaluate the impact of restrictions on outpatient access in the clinical management of the patient with acromegaly during COVID19 pandemi...

Introduction: The long pentraxine-3 (PTX3) is a key component of humoral innate immunity that is expressed in various cell types during stress and tissue injury. PTX3 also acts like an oncosuppressor regulating tumor-promoting inflammation and it is implicated in tissue repair and autoimmunity. Autoimmune disease, tissue remodelling and oncogenesis often coexist in the thyroid. PTX3 role in thyroid disease is still unknown. Aim of the study is to evaluate if plasmatic levels o...

Introduction: Neuroendocrine neoplasms (NEN) are heterogeneous tumors, usually sporadic and non-functioning, with a favorable long-term prognosis if localized. Metastases are common and survival outcomes of metastatic patients (pts) is worse than in localized disease.Aim: To investigate survival outcomes in a monocentric cohort of sporadic NEN.Materials and Methods: Clinical data of pts with histologically confirmed sporadic NEN, r...